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AssigneeSchering Corporation
InventorsUlrich Kerb, Rudolf Wiechert, Klaus Kieslich, Karl Petzoldt, Helmut Wachtel, Dieter Palenschat, Reinhard Horowski, Gert Paschelke, Wolfgang Kehr
Estimating the term…
D-homo-20-ketopregnanes of the formula ##STR1## wherein R.sub.1 is oxygen, ##STR2## in which R.sub.5 is hydrogen or lower acyl; R.sub.2 is hydrogen or methyl; R.sub.3 is oxygen, ##STR3## or two hydrogen atoms; R.sub.4 is hydrogen, hydroxy or acyloxy; R.sub.6 is hydrogen or methyl; and R.sub.7 is hydrogen, acetyl, hydroxy or lower acyloxy in the .alpha.- or .beta.-position possess CNS-depressant activity, including anesthesia upon parenteral administration, and are produced by hydrogenating the corresponding steroids having double bonded C.sub.5 and/or C.sub.16 carbon atoms.
A D-homo-20-ketopregnane of the formula ##STR8## wherein R.sub.1 is an oxygen atom ##STR9## in which R.sub.5 is hydrogen or the acyl radical of a hydrocarbon carboxylic or sulfonic acid of up to 8 carbon atoms;
3.alpha.-Hydroxy-D-homo-5.alpha.-pregnan-20-one.
3.alpha.-Hydroxy-D-homo-5.alpha.-pregnane-11,20-dione.
A method of inducing general anesthesia in a mammal which comprises administering thereto an amount effective to induce general anesthesia of a compound of the formula ##STR11## wherein R.sub.1 is an oxygen atom ##STR12## in which R.sub.5 is hydrogen or the acyl radical of a hydrocarbon carboxylic or sulfonic acid of up to 8 carbon atoms;
Dependencies are inferred from the claim text.