3-Amino-1-phenyl-1h,5h,-benzo-2,4-thiazepines
AssigneeSandoz Ltd.
InventorJohn Bernard Bream
Life of this patent
Estimating the term…
Abstract
This invention provides new compounds of formula I, ##STR1## wherein R.sub.1 and R.sub.2 are independently hydrogen, halogen, trifluoromethyl, lower alkoxy or lower alkyl, R.sub.3 is hydrogen, lower alkyl, lower hydroxyalkyl, or phenylalkyl of 7 to 10 carbon atoms, wherein the phenyl ring is unsubstituted or mono-substituted, or independently di-substituted, by halogen, lower alkyl, lower alkoxy, amino, lower alkylamino or di(lower alkyl)amino, and R.sub.4 is hydrogen, lower alkyl or lower hydroxyalkyl, Useful as anti-arrhythmics and anti-depressants.
Claims69
A compound of formula I, ##STR30## wherein R.sub.1 and R.sub.2 are independently hydrogen, halogen, trifluoromethyl, lower alkoxy or lower alkyl,
- R.sub.3 is hydrogen, lower alkyl, lower hydroxyalkyl, or phenylalkyl of 7 to 10 carbon atoms, wherein the phenyl ring is unsubstituted or mono-substituted, or independently di-substituted, by halogen, lower alkyl, lower alkoxy, amino, lower alkylamino or di(lower alkyl)amino, and
- R.sub.4 is hydrogen,
- in free base form or in pharmaceutically acceptable acid addition salt form thereof.
A compound of the formula ##STR31## wherein R.sub.1 and R.sub.2 are independently hydrogen, halogen, trifluoromethyl, lower alkoxy or lower alkyl,
- R.sub.3 is hydrogen, lower alkyl, or phenylalkyl of 7 to 10 carbon atoms, wherein the phenyl ring is unsubstituted or mono-substituted, or independently di-substituted, by halogen, lower alkyl, lower alkoxy, or di (lower alkyl)amino, and
- R.sub.4 is hydrogen, lower alkyl or lower hydroxyalkyl,
- in free base form or in pharmaceutically acceptable acid addition salt form thereof.
Dependencies are inferred from the claim text.