2-Alkyl-5-thiazole-carboxylic acid derivatives in hypolipemiant compositions
AssigneeRoussel Uclaf
InventorsFrancois Clemence, Odile Le Martret
Life of this patent
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Abstract
Hypolipemiant compositions comprising an effective amount of at least one 2-alkyl-5-thiazole-carboxylic acid derivative of the formula ##STR1## wherein R is hydrogen, an alkali metal, ammonium, the monovalent residue of an organic base or a substituted or unsubstituted alkyl and where R'.sub.1 is a linear alkyl of 1 to 12 carbon atoms, and a major amount of a pharmaceutical carrier; as well as the method of reducing the amount of sanguine lipids in warm-blooded animals utilizing the above-hypolipemiant compositions.
Claims12
A hypolipemiant composition comprising an effective amount of at least one 2-alkyl-5-thiazolecarboxylic acid derivative of the formula ##STR13## wherein R is a member selected from the group consisting of hydrogen, an alkali-metal, triethylammonium, diisopropylammonium, diethylammonium, ethanolammonium, collidinium, morpholinium, piperidinium, alkyl having 1 to 10 carbon atoms, benzyl, the alkyl residue of an alkylheterocyclic alcohol the alkyl residue of which contains 1 to 6 carbon atoms and of which the heterocyclic residue is selected from the group consisting of furyl, thienyl and pyridyl, .alpha.-glyceryl, diethylaminoethyl, diethylaminopropyl and dipropylaminoethyl, and R'.sub.1 [R'] is a linear alkyl of 1 [3] to 12 carbon atoms, and a major amount of a pharmaceutical carrier.
A hypolipemiant composition comprising an effective amount of at least one 2-alkyl-5-thiazolecarboxylic acid derivative of the formula ##STR14## wherein R is a member selected from the group consisting of hydrogen, an alkali metal, triethylammonium, diisopropylammonium, diethylammonium, ethanolammonium, collidinium, morpholinium, piperidinium, and alkyl having 1 to 10 carbon atoms and [R'] R'.sub.1 is a linear alkyl of [3] 1 to 12 carbon atoms, and a major amount of a pharmaceutical carrier.
A method of reducing the amount of sanguine lipids in warm-blooded animals which comprises administering to said warm-blooded animals a safe and effective amount of at least one 2-alkyl-5-thiazolecarboxylic acid derivative of the formula ##STR15## wherein R is a member selected from the group consisting of hydrogen, an alkali-metal, triethylammonium, diisopropylammonium, diethylammonium, ethanolammonium, collidinium, morpholinium, piperidinium, alkyl having 1 to 10 carbon atoms, benzyl, the alkyl residue of an alkylheterocyclic alcohol the alkyl residue of which contains 1 to 6 carbon atoms and of which the heterocyclic residue is selected from the group consisting of furyl, thienyl and pyridyl, .alpha.-glyceryl, .beta.-glyceryl, diethylaminoethyl, diethylaminopropyl and dipropylaminoethyl, and R'.sub.1 is a linear alkyl of 1 to 12 carbon atoms.
A method of reducing the amount of sanguine lipids in warm-blooded animals which comprises administering to said warm-blooded animals a safe and effective amount of at least one 2-alkyl-5-thiazolecarboxylic acid derivative of the formula ##STR16## wherein R is a member selected from the group consisting of hydrogen, an alkali metal, triethylammonium, diisopropylammonium, diethylammonium, ethanolammonium, collidinium, morpholinium, piperidinium, and alkyl having 1 to 10 carbon atoms and R'.sub.1 is a linear alkyl of 1 to 12 carbon atoms.
Dependencies are inferred from the claim text.