Piperidyl-glycylamide derivatives
AssigneeJohn Wyeth & Brother Limited
InventorsJohn Leheup Archibald, John Lambert Jackson
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Abstract
This invention relates to compounds having the general formula: ##STR1## wherein W represents a phenyl or indolyl radical, either of which radicals may be unsubstituted or substituted by halogen, lower alkyl, lower alkoxy or hydroxy; A represents a lower alkylene radical an oxo lower alkylene radical or a hydroxy lower alkylene radical; R represents a phenyl radical optionally substituted by halogen, lower alkyl, lower alkoxy or hydroxy, or a cycloalkyl radical of 5 to 7 carbon atoms; R.sup.1 represents hydrogen or a lower alkyl radical or a pharmaceutically acceptable acid addition or quaternary ammonium salt thereof; which possess hypotensive activity.
Claims10
A compound having the general formula:
- ##STR23## wherein W represents a phenyl or 3-indolyl radical, either of which radicals may be unsubstituted or substituted by halogen, lower alkyl, lower alkoxy or hydroxy;
- A represents a lower alkylene radical, an oxo lower alkylene radical or a hydroxy lower alkylene radical;
- R represents a phenyl radical optionally substituted by halogen, lower alkyl, lower alkoxy or hydroxy, or a cycloalkyl radical of 5 to 7 carbon atoms radical;
- R.sup.1 represents hydrogen or a lower alkyl radical;
- or a pharmaceutically acceptable acid addition or quaternary ammonium salt thereof.
Dependencies are inferred from the claim text.