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US 4,045,552 AGranted
Protease-free proteins, and methods of manufacturing and using the same
AssigneeBayer Aktiengesellschaft
InventorsCarl Kutzbach, Alfred Arens, Gunter Schmidt-Kastner
Life of this patent
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Abstract
Protease-free proteins, especially protease-free kallikrein, which are prepared by contacting a solution of the protein with a carrier-bound water-insoluble protease inhibitor that does not bind to said protein, and have improved storage stability in solution.
Claims10
A method of removing protease from kallikrein, comprising contacting a solution of the kallikrein with a carrier-bound water-insoluble polypeptide protease inhibitor that does not bind to said kallikrein, and recovering a protease-free kallikrein.
Dependencies are inferred from the claim text.