Process for the manufacture of thioformamido-phosphono-acetates
AssigneeCiba-Geigy Corporation
InventorJacques Gosteli
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Abstract
Thioformamidophosphono-acetates are prepared by reacting an isocyano compound of the formula C=N--CH.sub.2 --X.sub.1 in the presence of a base with a compound of the formula R.sub.o --X.sub.2, in which compounds one of the groups X.sub.1 and X.sub.2 represents a protected carboxyl group of the formula --C(=O)--OR.sub.1 and the other a disubstituted phosphono group of the formula --P(.fwdarw.O)(OR).sub.2, and wherein R.sub.o represents a reactive etherified or esterified hydroxyl group, and adding hydrogen sulphide on to the isocyano group of the phosphono-isocyano-acetate formed as an intermediate.
Claims13
A process for the manufacture of a thioformamidophosphono-acetate of the formula ##STR3## wherein R represents lower alkyl, aryl or aryl-lower alkyl and R.sub.1 represents a radical which protects the carboxyl group, characterized in that an isocyano compound of the formula C.dbd.N--CH.sub.2 --X.sub.1 (II) is reacted in the presence of a base with a compound of the formula R.sub.o --X.sub.2 (III), one of the radicals X.sub.1 and X.sub.2 representing a group of the formula --C(.dbd.O)--OR.sub.1 (A) and the other representing a group of the formula --P(.fwdarw.O)(OR).sub.2 (B) and R.sub.o representing halogen or a reactive etherified or esterified hydroxyl group, and hydrogen sulphide is added on to the isocyano group of a resulting phosphono-isocyano-acetate of the formula ##STR4##
Dependencies are inferred from the claim text.