Aminophenyltetralin compounds
AssigneePfizer Inc.
InventorReinhard Sarges
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Abstract
A series of novel 4-phenyl-1,2,3,4-tetrahydro-1-naphthylamines, including their pharmaceutically acceptable acid addition salts and their cis- and trans-isomers, have been prepared. The trans-isomers are useful in the field of mental health as antidepressant agents and/or as psychomotor stimulants. The trans-isomer of N-methyl-4-phenyl-1,2,3,4-tetrahydro-1-naphthylamine represents a preferred embodiment.
Claims13
A compound selected from the group consisting of the trans-isomers of 1-amino-4-phenyltetralin bases of the formula:
- ##STR3## and the pharmaceutically acceptable acid addition salts thereof, wherein R.sub.1 is a member selected from the group consisting of hydrogen and alkyl having from one to three carbon atoms, and R.sub.2 is a member selected from the group consisting of alkyl having from one to three carbon atoms and cycloalkyl having from three to six carbon atoms, said R.sub.2 only being cycloalkyl when r.sub.1 is hydrogen.
Trans-dl-N-methyl-4-phenyl-1,2,3,4-tetrahydro-1-naphthylamine.
Trans-d-N-methyl-4-phenyl-1,2,3,4-tetrahydro-1-naphthylamine.
Trans-dl-N-Ethyl-4-phenyl-1,2,3,4-tetrahydro-1-naphthylamine.
Trans-dl-N,N-Dimethyl-4-phenyl-1,2,3,4-tetrahydro-1-naphthylamine.
Dependencies are inferred from the claim text.