16-Cyclobutyl-prostaglandins
AssigneeOno Pharmaceutical Co., Ltd.
InventorsMasayasu Kurono, Hisao Nakai, Takashi Muryobayashi
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Abstract
Prostaglandin analogues of the formula: ##STR1## wherein A represents a grouping of the formula: ##STR2## X represents trans-vinylene or ethylene and Y represents cis-vinylene or ethylene, R represents hydrogen or alkyl of 1 through 12 carbon atoms, R.sup.1, R.sup.2 and R.sup.3 represent hydrogen, or alkyl of 1 through 12 carbon atoms or an aryl group, with the proviso that at least one of the symbols R.sup.1, R.sup.2 and R.sup.3 represents an alkyl or aryl group, are new compounds possessing useful pharmacological properties; they are especially useful for the treatment of gastric ulceration.
Claims9
A compound of the formula:
- ##STR18## wherein R represents a hydrogen atom or methyl group, R.sup.1 and R.sup.2 represent hydrogen atoms and R.sup.3 represents an alkyl group containing from 1-6 carbon atoms, the non-toxic salts thereof when R is hydrogen, the C.sub.1 to C.sub.12 alkyl esters thereof, and the cyclodextrin clathrates thereof.
16,17-ethano-16-phenyl-.omega.-trinor-PGE.sub.2.
Dependencies are inferred from the claim text.