Cyanoprostaglandins
AssigneePfizer Inc.
InventorsHans-Jurgen E. Hess, Thomas K. Schaaf
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Abstract
The 19-cyano-20-nor derivatives of prostaglandins E.sub.1 and E.sub.2, and certain esters thereof, are bronchodilatory agents, useful in the treatment of bronchial asthma, bronchitis, pneumonia and emphysema. The 19-cyano-20-nor derivatives of prostaglandins E.sub.1 and E.sub.2, and certain esters thereof, which also have protecting groups on the hydroxy groups at C-11 and C-15 are useful intermediates for the preparations of the bronchodilatory agents of this invention.
Claims3
A compound of the formula ##STR9## wherein R.sup.2 is selected from the group consisting of hydrogen, alkyl having from one to four carbon atoms and 4-biphenylyl;
- and Z represents a single bond or a cis double bond.
Dependencies are inferred from the claim text.