Optical resolution of DL-pantolactone
AssigneeAlps Pharmaceutical Ind. Co., Ltd.
InventorsAkikazu Kinugasa, Toshio Okuda, Makoto Goto, Mitsuo Saito
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Abstract
The optical resolution of DL-pantolactone is effected by reacting DL-pantolactone or its alkali salt derived therefrom, respectively, with an optically active N-substituted aminophenylpropanol of the general formula: ##STR1## wherein R.sub.1 is a phenyl group which may be substituted and R.sub.2 is an aralkyl group in which the benzene ring may bear a substituent, or its mineral acid addition salt; separating the resulting diastereomers by the aid of difference in their dissolubility; and decomposing them to give the corresponding optical antipodes. This method can provide the antipodes in high purity and yield and can be carried out with ease.
Claims13
A method of optically resolving DL-pantolactone which comprises reacting DL-pantolactone or its basic salt with an opticaly active N-substituted aminophenylpropanol of the general formula:
- ##STR3## wherein R.sub.1 is a phenyl group which may be substituted by a halogen atom, an aliphatic lower alkyl group having from 1 to 4 carbon atoms or an aliphatic lower alkoxy group having a 1 to 4 carbon atom alkyl and R.sub.2 is an aralkyl group having from 7 to 10 carbon atoms which may be substituted on the benzene ring by a halogen atom, an aliphatic lower alkyl having from 1 to 4 carbon atoms or an aliphatic lower alkoxy whose alkyl has from 1 to 4 carbon atoms, or a mineral acid addition salt, respectively, separating the resulting diastereomer by the aid of difference in their dissolubility and decomposing the diastereomer into the corresponding antipode.
Dependencies are inferred from the claim text.