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US 4,045,444 AGranted
Benzamido piperidines
AssigneeJohn Wyeth & Brother Limited
InventorsJohn Frederick Cavalla, John Leheup Archibald
Life of this patent
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Abstract
A group of heterocyclic compounds useful in the treatment of disorders and diseases of the cardiovascular system is described. These compounds are piperidine compounds linked by the nitrogen atom to a methylenedioxyphenyl or an ethylenedioxyphenyl radical through the intermediary of a group selected from a mono-keto lower alkylene radical or a hydroxy-lower-alkylene radical or a bivalent radical of the formula ##STR1## or --O--(lower alkylene). The piperidine rings are further substituted by a benzamido residue.
Claims3
A compound selected from the group consisting of
- A. heterocyclic compounds of the formula ##STR23## in which W represents a member of the group consisting of 3,4 methylene- or 3,4 ethylene-dioxyphenyl, A represents a bivalent radical selected from the group consisting of mono-keto lower alkylene, hydroxy lower alkylene and radicals having the formula--OCH.sub.2 CHOHCH.sub.2 or --O-- loweralkylene, R represents phenyl and the term "lower" means that the radical contains from 1 to 6 carbon atoms and (B) the pharmaceutically acceptable acid addition and quaternary ammonium salts thereof.
Dependencies are inferred from the claim text.