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US 4,045,442 AGranted
1-(Substituted amino)alkanoyl-2-(dibenzoxazepine-10-carbonyl)hydrazines and derivatives thereof
AssigneeG. D. Searle & Co.
InventorRichard A. Mueller
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Abstract
The reaction of 1-(halo/cyano/sulfonyloxy)alkanoyl-2-(dibenzoxazepine-10-carbonyl)hydrazin es with an amine affords the corresponding 1-(substituted amino)alkanoyl-2-(dibenzoxazepine-10-carbonyl)hydrazines which compounds are useful anti-inflammatory or anti-diarrheal agents.
Claims10
A compound of the formula
- wherein X and Y represent hydrogen, halogen, lower alkyl having 1-7 carbon atoms, trifluoromethyl;
- alk represents lower alkylene having 1-6 carbon atoms;
- R' and R" together
- with N represents an azamonocyclic ring wherein the azamonocyclic ring is pyrrolidino, 2,5-dimethylpyrrolidino, hexahydroazepine, piperidino, 4-ethoxycarbonyl-4-phenylpiperidino, 4-hydroxy-4-phenylpiperidino, 4-carboxy-4-phenylpiperidino, and R"' represents hydrogen or lower alkyl having 1-4 carbon atoms.
1 more element
Dependencies are inferred from the claim text.