6-Substituted-4-hydroxycinnolin-3-yl carboxylic acids and esters thereof
AssigneeImperial Chemical Industries PLC
InventorsJohn Preston, Austin John Reeve
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Abstract
6-Substituted-4-hydroxycinnolin-3-yl carboxylic acids and esters thereof, processes for their preparation, and pharmaceutical compositions comprising any one of these compounds. A representative compound is ethyl 6-glycylamino-4-hydroxycinnolin-3-yl carboxylate hydrochloride. The compounds are active as inhibitors of effects following the combination of reagin-like antibodies and their antigens.
Claims5
A cinnoline derivative selected from the group consisting of ethyl 6-cyclopentylamino-4-hydroxycinnolin-3-yl carboxylate, ethyl 4-hydroxy-6-isopropylaminocinnolin-3-yl carboxylate, ethyl 4-hydroxy-6-L-phenylalanylaminocinnolin-3-yl carboxylate and ethyl 4-hydroxy-6-thienylcinnolin-3-yl carboxylate, and pharmaceutically-acceptable acid-addition salts thereof.
Dependencies are inferred from the claim text.