Antibiotic XK-62-2 and process for production thereof
AssigneeAbbott Laboratories
InventorsTakashi Nara, Seigo Takasawa, Ryo Okachi, Isao Kawamoto, Mitsuyoshi Yamamoto, Seiji Sato, Tomoyasu Sato, Atsuko Morikawa
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Abstract
The antibiotic XK-62-2 is produced by fermentation of microorganisms belonging to the genus Micromonospora. The antibiotic is accumulated in the culture liquor and is isolated therefrom.
Claims12
A process for the production of the antibiotic XK- 62-2 which comprises;
- culturing a microorganism belonging to the species Micromonospora sagamiensis, which is capable of producing XK-62-2, in a nutrient medium until substantial antibacterial activity is detected in the culture liquor;
- and thereafter isolating said antibiotic therefrom.
A process for the production of the antibiotic XK-62-2, which comprises;
- culturing an XK-62-2 producing microorganism selected from the group consisting of Micromonospora sagamiensis ATCC 21826, Micromonospora sagmiensis var. flava ATCC 21827, Micromonospora sagamiensis var. nonreducans ATCC 21803 and ATCC 21949, Micromonospora echinospora ATCC 15837, Micromonospora echinospora var. ferruginea ATCC 15836, Micromonospora echinospora var. pallida ATCC 15838 and Micromonospora purpurea ATCC 15835 in a nutrient medium;
- accumulating XK-62-2 in said medium;
- and isolating the antibiotic XK-62-2 therefrom.
A process for the production of the antitiotics gentamicin C.sub.1, gentamicin C.sub.2 and gentamicin C.sub.1a which comprises culturing a microorganism belonging to the species Micromonospora sagamiensis which is capable of producing said antibiotics in a nutrient medium until substantial antibacterial activity is detected in the culture liquor;
- and thereafter isolating at least one of said antibiotics therefrom.
Dependencies are inferred from the claim text.