Preparation of optically clear serum
OwnerGary J. Proksch, Dean P. Bondermaninventors
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Abstract
A stable optically clear serum is prepared for use in the preparation of standards and quality control reference material for the assay of human serum components. In one aspect of the present invention, high density lipoproteins isolated from human blood serum are added to substantially human serum to produce a standard or reference material. A second aspect of the present invention involves the addition of isolated, non-primate lipoproteins to substantially human serum. The serum prepared as disclosed has good optical clarity upon lyophilization and reconstitution with aqueous media. Alternatively, the isolated lipoproteins are added in an aqueous diluent to lyophilized human serum.
Claims20
A substantially human serum for use as a standard or reference material is assaying human blood, said human serum being improved by containing in addition to essentially all normal human serum components, isolated non-primate, animal lipoproteins which contain cholesterol.
A substantially human serum for use as a standard or reference material in assaying human blood, said human serum being improved by containing in addition to essentially all normal human serum components, isolated non-primate, animal lipoproteins which contain mainly low density lipoproteins.
A lyophilized substantially human serum for use as a standard or reference material in assaying human blood, said human serum having its triglyceride level significantly reduced but containing high density lipoproteins and essentially all other serum components normally present in human serum.
A substantially human serum for use as a standard or reference material in assaying human blood, said human serum having normally present lipoproteins removed, but containing non-primate, animal lipoproteins.
A method of preparing a substantially human serum for use as a standard or reference material which comprises the addition of isolated high density lipoproteins to human serum.
A method of preparing a substantially human serum for use as a standard or reference material which comprises the addition of isolated, high density lipoproteins to lyophilized human serum.
A method of preparing a substantially human serum for use as a standard or reference material which comprises the addition of non-primate, animal lipoproteins to lyophilized human serum.
Dependencies are inferred from the claim text.