Chromatographic separation columns with selectively modified active surfaces and methods for their preparations
AssigneeIndiana University Foundation
InventorsMilos V Novotny, Karel Grohmann
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Abstract
Selective monomolecular layers on siliceous surfaces used for the construction of high-resolution chromatographic columns are prepared by surface reactions with monohalogenated silanes, silazanes or silylamines, or monoalkoxy- or monoacetoxysilanes, and subsequent chemical modifications. Such monolayers form a basis for efficient films of chemically compatible stationary phases by introducing selective groups in gas-liquid chromatography and all forms of liquid chromatography, or for adsorbent modifications in gas-solid chromatography.
Claims4
A method of preparing chromotographic columns comprising active surfaces fabricated of a siliceous material which method includes the step of modifying said surfaces by reaction with chlorodimethyl (4-(4-chloromethylphenyl)butyl) silane.
A chromatographic column comprising active surfaces fabricated of siliceous material carrying a monomolecular layer thereon mechanically and chemically compatible with a stationary phase to be applied thereto, said layer being formed of chlorodimethyl (4-(4-chloromethylphenyl) butyl silane.
Dependencies are inferred from the claim text.