Methods and applications of preparative scale chromatography
AssigneeNational Research Development Corporation
InventorCourtenay Stanley Goss Phillips
Life of this patent
Estimating the term…
Abstract
A preparative scale chromatographic method in which a mixture is chromatographically fractionated on a sorbent material by the displacing action of a sorbate which is thermally displaced through the material by a heated zone advancing through the material to leave behind sorbent material substantially free of said sorbate. In an application of particular interest, at least one component of the mixture is produced by catalytic reaction of one or more thermally displaced sorbates induced by the heated zone of sorbent material.
Claims10
A chromatographic method for fractionating a mixture of sorbate components in a continuous operation comprising:
- providing a flow path of sorbent having different affinities for the sorbate components of said mixture;
- feeding said mixture into said flow path of sorbent;
- and
- thermally displacing a sorbate through said sorbent in advance of a substantially uniform heat zone of limited width to fractionate said sorbate components into an abutting succession of components in accordance with the affinities of said components for said sorbent by relative movement between the sorbent and the heat zone, the mixture being fractionated into sorbate components in the advancing relatively cool area of sorbent ahead of said heat zone, the amount of all sorbate components falling into said heat zone being relatively insignificant.
Dependencies are inferred from the claim text.