US 4,039,575 AGranted

Alkanimidoylthioureas

AssigneeSterling Drug Inc.

InventorGuy D. Diana

Life of this patent

Estimating the term…

Abstract

The compounds of this invention are novel alkanimidoylthioureas having antifertility activity. They are prepared by the reaction of appropriate alkanamidines with appropriate isothiocyanates.

Claims10

Dependent claims

A compound selected from the group consisting of 1-(4-chlorophenyl)-3-(4,4-dimethylpentanimidoyl)-2-thiourea, 1-(4-chlorophenyl)-3-(hexanimidoyl)-2-thiourea, 1-(4-chlorophenyl)-3-(heptanimidoyl)-2-thiourea, 1-(4-bromophenyl)-3-(heptanimidoyl)-2-thiourea, 1-(4-fluorophenyl)-3-(heptanimidoyl)-2-thiourea, 1-(4-iodophenyl)-3-(heptanimidoyl)-2-thiourea, 1-(3-chlorophenyl)-3-(heptanimidoyl)-2-thiourea, 1-(2,4-dibromophenyl)-3-(heptanimidoyl)-2-thiourea, 1-(2-chloro-4-methylphenyl)-3-(heptanimidoyl)-2-thiourea, 1-(4-chlorophenyl)-3-(octanimidoyl)-2-thiourea and 1-(4-chlorophenyl)-3-(nonanimidoyl)-2-thiourea, and acid-addition salts thereof.

Dependencies are inferred from the claim text.

Facts

Application: 05/669,229Filed 22 Mar 1976 · continuation in part
Priority: 7 Mar 1968
Granted: 2 Aug 1977
Term ends: Not estimatedThe source records don’t support an estimate.

Classification8 codes

C07D 295/15
With the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted…
A61K 31/17
Amides, e.g. hydroxamic acids: having the group >N—C—N< or >N—C—N<, e.g. urea, thiourea, carmustine
C07C 275/56
Y being a hydrogen or a carbon atom: x being a nitrogen atom
C07D 307/70
With hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals,…:…

Family

Serial711,235Parent of this continuation-in-part · filed 7 Mar 1968
Serial15,875Parent of this continuation-in-part · filed 2 Mar 1970
Serial418,087Parent of this continuation-in-part · filed 21 Nov 1973
US 3,984,467 AParent of this continuation-in-part
3830839Parent of this continuation-in-part
3629455Parent of this continuation-in-part
US 4,039,575 AThis patent

From the US filing history. Foreign family members aren’t listed.

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Abstract

The compounds of this invention are novel alkanimidoylthioureas having antifertility activity. They are prepared by the reaction of appropriate alkanamidines with appropriate isothiocyanates.

Facts

Application

05/669,229Filed 22 Mar 1976 · continuation in part

Priority

7 Mar 1968

Granted

2 Aug 1977

Term ends

Not estimatedThe source records don’t support an estimate.

Classification8 codes

C07D 295/15
With the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted…
A61K 31/17
Amides, e.g. hydroxamic acids: having the group >N—C—N< or >N—C—N<, e.g. urea, thiourea, carmustine
C07C 275/56
Y being a hydrogen or a carbon atom: x being a nitrogen atom
C07D 307/70
With hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals,…:…

Family

Serial711,235Parent of this continuation-in-part · filed 7 Mar 1968

Serial15,875Parent of this continuation-in-part · filed 2 Mar 1970

Serial418,087Parent of this continuation-in-part · filed 21 Nov 1973

US 3,984,467 AParent of this continuation-in-part

3830839Parent of this continuation-in-part

3629455Parent of this continuation-in-part

US 4,039,575 AThis patent

From the US filing history. Foreign family members aren’t listed.