Anti-inflammatory oxazole[4,5-b]pyridines
AssigneeMerck & Co., Inc.
InventorsTsung-Ying Shen, Robert L. Clark, Arsenio A. Pessolano, Bruce E. Witzel, Thomas J. Lanza
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Abstract
The various isomers of oxazolo- and thiazolopyridines having utility as antiinflammatory, antipyretic and analgesic agents are prepared by condensation of an appropriate amino-hydroxypyridine or amino-mercaptopyridine with a carboxylic acid, halide or anhydride.
Claims36
A compound of structural formula:
- ##STR48## wherein n is an integer from 1 to 2 and X is the same or different and is halo, lower alkyl, trifluoromethyl, lower alkoxy, nitro or cyano.
2-(2-Fluorophenyl)oxazolo[4,5-b]pyridine.
2-(2-Cyanophenyl)oxazolo[4,5-b]pyridine.
2-(2,6-Difluorophenyl)oxazolo[4,5-b]pyridine.
2-(3-Methoxyphenyl)oxazolo[4,5]pyridine.
2-(3,5-Dimethylphenyl)oxazolo[4,5-b]pyridine.
2-(2-Methyl-3-chlorophenyl)oxazolo[4,5-b]pyridine.
2-(2-Chloro-3-methylphenyl)oxazolo[4,5-b]pyridine.
2-(2-Methyl-3-methoxyphenyl)oxazolo[4,5-b]-pyridine.
2-[3,5-di-(t-butyl)phenyl)oxazolo[4,5-b]pyridine.
2-(3-t-Butylphenyl)oxazolo[4,5-b]pyridine.
2-(3-t-Butyl-5-methylphenyl)oxazolo[4,5-b]pyridine.
2-(3-t-Butyl-5-methoxyphenyl)oxazolo[4,5-b]pyridine.
A method of treating inflammation, fever or pain in warm-blooded animals and humans in need of such treatment which comprises administration of an effective amount of a compound of structural formula:
- ##STR49## wherein n is an integer from 1 to 2 and X is the same or different and is halo, lower alkyl, trifluoromethyl, lower alkoxy, nitro or cyano.
A method for the treatment of inflammation, fever or pain in warm-blooded animals and humans in need of such treatment which comprises systemic administration of an effective amount of a compound of structural formula:
- ##STR50## wherein n is an integer from 1 to 2 and X is the same or different and is fluoro, nitro or cyano.
A method for the treatment of the inflammation of dermatoses in warm-blooded animals and humans in need of such treatment which comprises topical administration of an effective amount of a compound of structural formula:
- ##STR51## wherein n is an integer from 1 to 2 and X is the same or different and is chloro, lower alkyl, trifluoromethyl or lower alkoxy.
A pharmaceutical composition for systemic administration in the treatment of inflammation, fever or pain in warm-blooded animals and humans in need of such treatment comprising an inert carrier and an effective amount of a compound of structural formula ##STR52## wherein n is an integer from 1 to 2 and X is the same or different and is fluoro, nitro or cyano.
A pharmaceutical composition suitable for topical administration in the treatment of the inflammation of dermatoses in warm-blooded animals and humans in need of such treatment comprising an inert carrier and an effective amount of a compound of structural formula:
- ##STR53## wherein n is an integer from 1 to 2 and X is the same or different and is chloro, lower alkyl, trifluoromethyl, or lower alkoxy.
Dependencies are inferred from the claim text.