Ethyleneimine inactivated microorganisms
AssigneeBayer Aktiengesellschaft
InventorsKurt Bauer, Gunther Wittmann, Manfred Mussgay, Eckart Irion, Horst Geilhausen
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Abstract
Microorganisms can be rendered inactive without impairing their antigenicity or immunogenicity by treating the microorganisms with ethyleneimine. The microorganism is placed in a suspension containing ethyleneimine up to a final concentration of 0.005% to 2% V/V. The temperature of the ethyleneimine-containing suspension is maintained between 0.degree. C and 45.degree. C for between a few hours and 2 days. The excess ethyleneimine is destroyed.
Claims31
A virus suspension to which ethyleneimine has been added such that the concentration of ethyleneimine is 0.005% to 2% V/V, the residual unused ethyleneimine thereafter being destroyed, whereby the virus is inactivated without impairment to its antigenicity or immunogenicity.
A method of rendering virus inactive without impairing its antigenicity or immunogenicity which comprises adding to a virus a suspension of ethyleneimine such that the concentration of ethyleneimine in the suspension is 0.005% to 2% V/V, maintaining the temperature of the suspension between 0.degree. C. and 45.degree. C. for between a few hours and 2 days, and thereby destroying the residual unused ethyleneimine.
Dependencies are inferred from the claim text.