Binding of antimicrobial compounds to a hydroxyl containing substrate with cyanuric chloride
AssigneeSchwarz Services International Ltd.
InventorsMortimer Wilkes Brenner, Louis Laufer
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Abstract
Methods and compositions are disclosed for chemically bonding an antimicrobial compound to an hydroxyl bearing substrate such as cellulose, starches or leather. Cyanuric chloride (2, 4, 6 tri-chloro 1, 3, 5 triazine) is bonded to the substrate through the substrate hydroxyl and to the antimicrobial through an amine, guanido or quaternary ammonium group. The composition is: ##STR1## R.sub.1 or R.sub.2 may be chlorine or the same or different amine, guanido or quaternary ammonium containing antimicrobial. The bonding process is carried out in an aqueous solution having a pH of about 9 - 10.
Claims5
The method of bonding an amine, guanido or quaternary ammonium containing antimicrobial compound selected from the group consisting of chlorhexidine acetate, streptomycin sulfate, neomycin sulfate, alkyl dimethyl benzyl ammonium chloride, trimethyl octyl decyl ammonium chloride, cetyl dimethyl benzyl ammonium chloride and mixtures thereof to a hydroxyl containing substrate taken from the group consisting of cellulose, starches and leather comprising the steps of:
- A. reacting the substrate with cyanuric chloride in a solution to chemically bond the cyanuric chloride to the substrate;
- B. and then reacting an effective amount of antimicrobial in solution with the cyanuric chloride on the substrate to chemically bond the cyanuric chloride to the antimicrobial, said cyanuric chloride being present in an amount effective to bond the antimicrobial to the substrate through the cyanuric chloride.
An antimicrobial composition comprising a hydroxyl containing substrate to which is bound cyanuric chloride and one or more amine, guanido or quaternary ammonium containing antimicrobial compounds selected from the group consisting of chlorhexidine acetate, streptomycin sulfate, neomycin sulfate, trimethyl octyl decyl ammonium chloride, alkyl dimethyl benzyl ammonium chloride, cetyl dimethyl benzyl ammonium chloride, and mixtures thereof, said antimicrobial compound being chemically bonded to the hydroxyl containing substrate through the cyanuric chloride.
A persistent antimicrobial composition comprising a cellulose substrate having chemically bound thereto a cyanuric chloride radical and one or more amine, guanido or quaternary ammonium containing antimicrobial radicals chemically bound to said cyanuric chloride radical to provide a composition of the formula ##STR4## wherein X is the substrate, R.sub.1 or R.sub.2 may be chlorine, and one or each of R.sub.1 and R.sub.2 is an antimicrobial radical, either the same or different, selected from the group consisting of chlorhexidine acetate, streptomycin, trimethyl octyl decyl ammonium chloride, bacitracin, tetracycline hydrochloride, neomycin sulfate, alkyldimethyl benzyl ammonium chloride and cetyl dimethyl benzyl ammonium chloride.
Dependencies are inferred from the claim text.