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US 4,032,522 AGranted
2-Pyrazinyl-trifluoromethylimidazoles and a method for their preparation
AssigneeMerck & Co., Inc.
InventorsJohn J. Baldwin, Frederick C. Novello
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Abstract
4(5)-Trifluoromethylimidazoles having optional substituents in the 1 and 2 positions are provided. The novel 4(5)-trifluoromethylimidazoles are prepared by reacting a 1,1-dihalo-3,3,3-trifluoroacetone compound with an appropriate carboxaldehyde and ammonia. The 4(5)-trifluoromethylimidazoles are useful as anti-gout and anti-hyperuricemic agents.
Claims3
A compound of the formula:
- ##STR9## and the nontoxic pharmacologically acceptable salts thereof;
- wherein R.sub.1 is hydrogen, lower alkyl or monohydroxy-C.sub.2 -C.sub.3 alkyl, and R.sub.2 is pyrazinyl or mono-methoxy substituted pyrazinyl.
A compound of the formula:
- ##STR10## and the non-toxic pharmacologically acceptable salts thereof;
- wherein R.sub.2 is pyrazinyl or mono-methoxy substituted pyrazinyl.
2-Pyrazinyl-4(5)-trifluoromethylimidazole.
Dependencies are inferred from the claim text.