Bandage for transdermally administering scopolamine to prevent nausea

A therapeutic system in the form of a bandage for administering scopolamine base through unbroken skin to inhibit emesis and nausea for a prolonged time period comprising a sandwich-type laminate of:

• (a) a backing lamina that is substantially impermeable to scopolamine base, one face of which forms the top of the bandage:
• (b) a scopolamine base reservoir lamina adjacent the opposite face of the backing lamina comprising
• i. (c) 0.2 to about 3 mg scopolamine base dispersed in a gelled mixture of
• (ii) mineral oil of about 10 to about 100 cp at 25.degree. C., and polyisobutene;
• (c) a microporous membrane lamina adjacent and below the scopolamine reservoir lamina through which the scopolamine base is released from the reservoir lamina after the bandage is affixed to the skin at a substantially constant rate in the range of about 0.3 to about 15 .mu.g/hr;
• and
• (d) a contact adhesive lamina adjacent and below the microporous membrane lamina by which said bandage is affixed to the skin comprising about 10 to about 200 .mu.g scopolamine base per cm.sup.2 effective surface area dispersed in a gelled mixture of said mineral oil and said polyisobutene.