Substituted 2-aminomethyl-6-iodophenols
AssigneeMerck & Co., Inc.
InventorsEdward J. Cragoe, Jr., Everett M. Schultz
Life of this patent
Estimating the term…
Abstract
Certain substituted 2-aminomethyl-6-iodophenols and their pharmaceutically acceptable acid addition salts wherein the phenyl nucleus may be further substituted with 1 to 3 nuclear substituents are useful as antihypertensive, diuretic and saluretic agents. These products may be prepared by either iodinating a 2-aminomethyl-3,4,5-substituted phenol or hydrolyzing an appropriately substituted N-(2-hydroxy-3-iodo-4,5,6-substituted benzyl)carboxamide under either acidic or basic conditions.
Claims14
A compound of the formula:
- ##STR16## wherein X.sup.1 is hydrogen, methyl or methoxy;
- X.sup.2 is lower alkyl containing from 3 to 5 carbon atoms;
- X.sup.3 is hydrogen, methyl, ethyl, methoxy or ethoxy
- or a non-toxic pharmaceutically acceptable salt thereof.
A compound of the formula:
- ##STR17## wherein X.sup.2 is lower alkyl containing from 3 to 5 carbon atoms or a non-toxic pharmaceutically acceptable acid addition salt thereof.
A compound of the formula:
- ##STR18## wherein X.sup.2 is a 4 or 5 carbon atom branched alkyl group wherein the branching occurs on the carbon atom attached to the ring or a non-toxic pharmaceutically acceptable acid addition salt thereof.
2-Aminomethyl-4-(1,1-dimethylethyl)-6-iodophenol or a non-toxic pharmaceutically acceptable acid addition salt thereof.
2-Aminomethyl-4-(1,1-dimethylethyl)-6-iodophenol.
2-Aminomethyl-4-(1,1-dimethylpropyl)-6-iodophenol or a non-toxic pharmaceutically acceptable acid addition salt thereof.
2-Aminomethyl-4(1-methylpropyl)-6-iodophenol or a non-toxic pharmaceutically acceptable acid addition salt thereof.
A pharmaceutical composition useful in the treatment of hypertension and edema which comprises from about 10 mg. ot 500 mg. of a compound of the formula:
- ##STR19## wherein X.sup.1 is hydrogen, methy or methoxy;
- X.sup.2 is lower alkyl containing from 3 to 5 carbon atoms;
- X.sup.3 is hydrogen, methyl, ethyl, methoxy or ethoxy or a non-toxic pharmaceutically acceptable salt thereof in an inert carrier.
A pharmaceutical composition useful in the treatment of hypertension and edema which comprises from about 10 mg. ot 500 mg. of a compound of the formula:
- ##STR20## wherein X.sup.2 is lower alkyl containing from 3 to 5 carbon atoms or a non-toxic pharmaceutically acceptable acid addition salt thereof in an inert carrier.
A pharmaceutical composition useful in the treatment of hypertension and edema which comprises from about 10 mg. to 500 mg. of a compound of the formula:
- ##STR21## wherein X.sup.2 is a 4 or 5 carbon atom branched alkyl group wherein the branching occurs on the carbon atom attached to the ring or a non-toxic pharmaceutically acceptable acid addition salt thereof in an inert carrier.
A pharmaceutical composition useful in the treatment of hypertension and edema which comprises from about 10 mg. ot 500 mg. of 2-aminomethyl-4-(1,1-dimethylethyl)-6-iodophenol or a non-toxic pharmaceutically acceptable acid addition salt thereof in an inert carrier.
Dependencies are inferred from the claim text.