Mercury intermediates useful in the preparation of 2-alkoxy cephalosporins
AssigneeE. R. Squibb & Sons, Inc.
InventorsWilliam A. Slusarchyk, Christopher M. Cimarusti
Life of this patent
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Abstract
Compounds of the formula ##STR1## WHEREIN R.sub.1 is lower alkyl, diphenylmethyl, 2,2,2-trichloro-ethyl, p-methoxybenzyl, or p-nitrobenzyl; R.sub.2 is hydrogen or acetoxy; R.sub.5 is lower alkyl; and R.sub.4 is ##STR2## wherein R.sub.3 is a heterocyclic group, lower alkyl, cycloalkyl, cycloalkenyl, cycloalkadienyl, phenyl, substituted phenyl, phenyl-lower alkyl, or phenoxy and X is hydrogen, protected amino or protected hydroxy provided that X is protected amino or protected hydroxy only when R.sub.3 is phenyl, substituted phenyl, or cycloalkadienyl, are disclosed. These compounds are useful as intermediates in the preparation of antibacterially active 2-alkoxy cephalosporins.
Claims9
A compound of the formula:
- ##STR68## wherein R.sub.1 is lower alkyl, diphenylmethyl, 2,2,2-trichloroethyl, p-methoxybenzyl, or p-nitrobenzyl;
- R.sub.2 is hydrogen or acetoxy;
- R.sub.5 is lower alkyl;
- and R.sub.4 is ##STR69## wherein X is hydrogen, protected amino of the formula ##STR70## or protected hydroxy of the formula ##STR71## and R.sub.3 is lower alkyl, cycloalkyl of 3 to 7 carbons, cycloalkenyl of 3 to 7 carbons, cycloalkadienyl of 6 to 7 carbons, phenyl, phenoxy, phenyllower alkyl, substituted phenyl wherein said substituent is one or two members selected from the group consisting of lower alkyl, lower alkoxy, and halogen, or heterocyclic wherein said heterocyclic is attached by way of an available carbon atom and is unsubstituted or substituted at an available carbon atom by a lower alkyl or halogen group and is selected from the group consisting of thienyl, furyl, pyrryl, pyridyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl, thiadiazolyl and tetrazolyl provided that X is protected amino or protected hydroxy only when R.sub.3 is phenyl, substituted phenyl or cycloalkadienyl.
Dependencies are inferred from the claim text.