Chromatographic supports and methods and apparatus for preparing the same

Abstract

Chromatographic supports are disclosed as are methods and apparatus for preparing the same. The support includes an inorganic support matrix that is capable of reacting with silanols, a stationary phase, and an intermediate silane coupling agent having a silicon functional group capable of bonding to the support surface and an organic functional group capable of bonding to the stationary phase. The inorganic support matrix is preferably controlled porosity glass or silica while the coupling agent may include a simple carbohydrate, a carbohydrate derivative, or a polymer to which the stationary phase is attached. A plurality of chromatographic supports and stationary phases are disclosed and two methods of bonding of stationary phases to supports are also disclosed. In addition, apparatus including a fluidized bed is also disclosed to prepare supports.

Dependencies are inferred from the claim text.