Chromogenic enzyme substrates
AssigneeA B Kabi
InventorsLeif Erik Aurell, Karl Goran Claeson
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Abstract
Chromogenic substrates for serine proteases, represented by the formula: R.sub.1 -A.sub.1 -A.sub.2 -Gly-Arg-NH-R.sub.2 or its salts, where R.sub.1 is hydrogen or alkanoyl having from 1 to 12 carbon atoms or cyclohexylcarbonyl or benzoyl or benzoyl substituted with one or two halogen atoms, methylamine or phenyl groups or benzene sulphonyl or toluenesulphonyl, R.sub.2 is nitrophenyl or naphthyl or nitronaphthyl or methoxynaphthyl or quinolyl or nitroquinolyl, A.sub.1 is a single bond or one of the amino acids Gly, Ala, Val, Leu, Ileu, Pro, Met, Phe or Tyr, and A.sub.2 is one of the amino acids Glu, Gln, Asp, or Asn.
Claims9
New chromogenic substrates for serine proteases, specially suitable for diagnostic determination of factor Xa, which are represented by the following general formula:
- R.sub.1 -A.sub.1 -A.sub.2 -Gly-Arg-NH-R.sub.2
- or its salts, where R.sub.1 is selected from the group consisting of hydrogen, alkanoyl having from 1 to 12 carbon atoms, cyclohexylcarbonyl, benzoyl, benzoyl substituted with one or two halogen atoms, methylamine or phenyl groups, benzene sulphonyl and toluenesulphonyl;
- R.sub.2 is selected from the group consisting of nitrophenyl, naphthyl, nitronaphthyl, methoxynaphthyl, quinolyl and nitroquinolyl;
- A.sub.1 is selected from the group consisting of a single bond, and the amino acids selected from the group consisting of Gly, Ala, Val, Leu, Ileu, Pro, Met, Phe and Tyr;
- and A.sub.2 is selected from the group consisting of the amino acids Glu, Gln, Asp, and Asn.
Dependencies are inferred from the claim text.