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AssigneeOtsuka Pharmaceutical Co., Ltd.
InventorsKazuyuki Nakagawa, Shiro Yoshizaki, Kaoru Tanimura, Shigeharu Tamada
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5-[1-Hydroxy-2-(substituted-amino)]alkyl -8-hydroxy-carbostyril derivatives represented by the formula (I) ##STR1## wherein R.sup.1 represents an alkyl group having 1 to 4 carbon atoms and R.sup.2 and R.sup.3, which may be the same or different, each represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, an aralkyl group containing a straight or branched chain alkyl moiety having 1 to 4 carbon atoms or a cycloalkyl group having 4 to 6 carbon atoms, or R.sup.2 and R.sup.3 may, when taken together with the nitrogen atom to which they are attached, form a 5- or 6-membered substituted or unsubstituted heterocyclic ring containing 1 or 2 nitrogen, oxygen or sulfur atoms as hetero atoms, the pharmaceutically acceptable acid addition salts thereof, and a process for preparing the same.
A 5-[1-hydroxy-2-(substituted-amino)]alkyl-8-hydroxy-carbostyril compound represented by the formula (I) ##STR16## wherein R.sup.1 represents an alkyl group having 1 to 4 carbon atoms and R.sup.2 and R.sup.3, which may be the same or different, each represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, a phenylalkyl group having a straight or branched chain alkyl moiety having 1 to 4 carbon atoms or a cycloalkyl group having 4 to 6 carbon atoms, or R.sup.2 and R.sup.3 may, when taken together with the nitrogen atom to which they are attached, form a 5- or 6- membered heterocyclic ring, substituted by an alkyl group having 1-4 carbon atoms or unsubstituted selected from the group consisting of pyrrolidino, piperidino, morpholino and piperazino and the pharmaceutically acceptable acid addition salts thereof.
A 5-[1-hydroxy-2-(substituted-amino)]alkyl-8-hydroxy-carbostyril compound represented by the formula (I) ##STR17## wherein R.sup.1 represents an alkyl group having 1 to 4 carbon atoms and R.sup.2 and R.sup.3, which may be the same or different, each represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, a phenylalkyl group having a straight or branched chain alkyl moiety having 1 to 4 carbon atoms or a cycloalkyl group having 4 to 6 carbon atoms, or R.sup.2 and R.sup.3 may, when taken together with the nitrogen atom to which they are attached, form a heterocyclic ring which is unsubstituted or substituted by an alkyl group having 1-4 carbon atoms, said heterocyclic ring being selected from the group consisting of piperidino and pyrrolidino, and the pharmaceutically acceptable acid addition salts thereof.
Dependencies are inferred from the claim text.