Tetracyclic compounds
AssigneeMerck Patent GmbH
InventorsWerner Rogalski, Richard Kirchlechner, Jurgen Seubert, Rudolf Gottschlich, Rosmarie Steinigeweg, Rolf Bergmann, Helmut Wahlig, Joachim Gante
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AssigneeMerck Patent GmbH
InventorsWerner Rogalski, Richard Kirchlechner, Jurgen Seubert, Rudolf Gottschlich, Rosmarie Steinigeweg, Rolf Bergmann, Helmut Wahlig, Joachim Gante
Estimating the term…
Tetracyclic compounds of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 each are H or alkyl, R.sup.5 is H, F, Cl, Br, CF.sub.3, OH, alkyl, alkoxy, NO.sub.2, NH.sub.2, alkylamino, dialkylamino or acylamino and X is O, S, SO, SO.sub.2, NH, N-alkyl or N-acyl, alkyl and alkoxy in each case being of 1-3 carbon atoms and acyl in each case being of 1-4 carbon atoms, with the proviso that when R.sup.5 is methoxy and X is a sulfur atom, R.sup.5 is in the 8- or 9-position only, and their physiologically acceptable acid addition salts, possess broad spectrum antibacterial activity, including tetracycline-resistant Gram-positive and Gram-negative organisms.
A tetracyclic compound of the formula ##STR10## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 in each case are H or alkyl;
A compound of the formula ##STR11## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 in each case are H or alkyl;
A compound of the formula ##STR12## wherein R.sup.3 and R.sup.4 are H or alkyl;
A tetracyclic compound of the formula ##STR13## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 in each case are H or alkyl;
Dependencies are inferred from the claim text.