Antiviral guanidino-urlido-benzene compounds
AssigneeImperial Chemical Industries PLC
InventorDouglas Lintin Swallow
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Abstract
The disclosure relates to novel aromatic compounds which possess antiviral activity, to processes for their manufacture and to a method of selectively inhibiting rhinovirus growth in the presence of other viruses.
Claims5
A compound of the formula:
- ##STR10## selected from the group consisting of those compounds wherein R.sup.1 is ethyl, R.sup.2 is bromophenyl, and the group --NH.CO.NHR.sup.2 is in the meta-position, those compounds wherein R.sup.1 is isopropyl, isobutyl, isopentyl or phenyl, R.sup.2 is chlorophenyl, bromophenyl, nitrophenyl, ethoxyphenyl or tolyl and the group --NH.CO.NHR.sup.2 is in the meta- or para-position, those compounds wherein R.sup.1 is chlorophenyl, R.sup.2 is alkyl of 3 to 10 carbon atoms and the group --NH.CO.NHR.sup.2 is in the meta-position, and those compounds wherein R.sup.1 is chlorophenyl or tolyl, R.sup.2 is phenyl or o-chlorophenyl and the group --NH.CO.NHR.sup.2 is in the para-position, and the acid addition salts thereof.
1-(3-Isobutylguanidino)-3-(3-p-chlorophenylureido)-benzene and the acid addition salts thereof.
A compound selected from 1-(3-ethylguanidino)-3-(3-p-bromophenylureido)benzene, 1-(3-isopropylguanidino)-3-(3-p-tolylureido)benzene, 1-(3-isobutylguanidino)-3-(3-m-chlorophenylureido)benzene, 1-(3-isobutylguanidino)-3-(3-o-chlorophenylureido)benzene, 1-(3-isobutylguanidino)-3-(3-p-bromophenylureido)benzene, 1-(3-isobutylguanidino)-3-(3-p-nitrophenylureido)benzene, 1-(3-isobutylguanidino)-3-(3-p-ethoxyphenylureido)benzene, 1-(3-isobutylguanidino)-3-(3-p-tolylureido)benzene, 1-(3-phenylguanidino)-3-(3-p-chlorophenylureido)benzene, 1-(3-p-chlorophenylguanidino)-3-(3-isobutylureido)benzene, 1-(3-p-chlorophenylguanidino)-3-(3-n-octylureido)benzene, 1-(3-isopropylguanidino)-4-(3-p-chlorophenylureido)benzene, 1-(3-isobutylguanidino)-4-(3-p-chlorophenylureido)benzene, 1-(3-isopentylguanidino)-4-(3-p-chlorophenylureido)benzene and 1-(3-isobutylguanidino)-4-(3-p-tolylureido)benzene and the acid addition salts thereof.
Dependencies are inferred from the claim text.