Anticalculus composition
AssigneeLever Brothers Company
InventorsLeonard J. Vinson, Lewis P. Cancro
Life of this patent
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Abstract
This invention relates to an improved composition for inhibiting dental plaque and calculus formation, comprising zinc ions and a non-toxic, organoleptically acceptable antibacterial agent in an orally acceptable medium, and to a process for retarding the growth of dental plaque and calculus by application to the teeth of the above composition.
Claims20
An oral composition capable of retarding the development of dental calculus consisting essentially of from about 0.05% to about 4% zinc ions and about 0.03% to about 0.5% of a non-toxic, organoleptically acceptable antibacterial agent capable of inhibiting the growth of gram-positive oral microflora for at least about three hours in an orally acceptable medium, said antibacterial agent being selected from the group consisting of 3,4',5-tribromosalicylanilide, the zinc derivative of 3,4',5-tribromosalicylanilide, 3,4',5-trichlorosalicylanilide, the zinc derivative of 3,4',5-trichlorosalicylanilide, 3,5-dibromo-4'-trifluromethylsalicylanilide, the zinc derivative of 3,5-dibromo-4'-trifluoromethylsalicylanilide, 2,4,4'-trichloro-2'-hydroxydiphenyl ether, tyrothricin, chlorhexidine digluconate, chlorhexidine diacetate, quaternary ammonium compounds wherein said quaternary ammonium compounds are diisobutylphenoxyethoxyethyldimethylbenzylammonium chloride, diisobutylcresoxyethoxyethyldimethylbenzylammonium chloride, N-methyl-N-(2-hydroxyethyl)-N-(2-hydroxydodecyl)N-benzyl ammonium chloride, cetyl trimethylammonium bromide, stearyl trimethylammonium bromide, oleyl dimethylethylammonium bromide, lauryldimethylchlorethoxyethylammonium chloride, lauryldimethylbenzylammonium chloride, alkyl(C.sub.8 -C.sub.18) dimethyl (3,4-dichlorobenzyl)-ammonium chloride, lauryl isoquinolinium bromide, N(lauroyloxyethylaminoformylmethyl)pyridinium chloride, and mixtures thereof.
An oral composition capable of retarding the development of plaque and dental calculus consisting essentially of zinc ions, and antibacterial agent and a particulate inorganic dental polishing agent, said zinc ions being present in the proportion of about 0.05% to about 4% and being furnished by a soluble zinc compound, said antibacterial agent being present within the range of about 0.03% to about 0.5%, and capable of inhibiting the growth of gram-positive oral microflora at least about three hours being selected from the group consisting of 3,4',5-tribromosalicylanilide, the zinc derivative of 3,4',5-tribromosalicylanilide, 3,4',5-trichlorosalicylanilide, the zinc derivative of 3,4',5-trichlorosalicylanilide, 3,5-dibromo-4'-trifluoromethylsalicylanilide, the zinc derivative of 3,5-dibromo-4'-trifluoromethylsalicylanilide, 2,4,4'-trichloro-2'-hydroxydiphenyl ether, tyrothricin, chlorhexidine digluconate, chlorhexidine diacetate, quaternary ammonium compounds wherein said quaternary ammonium compounds are diisobutylphenoxyethoxyethyldimethylbenzylammonium chloride, diisobutylcresoxyethoxyethyldimethylbenzylammonium chloride, N-methyl-N-(2-hydroxyethyl)-N-(2-hydroxydodecyl)N-benzylammonium chloride, cetyl trimethylammonium bromide, stearyl trimethylammonium bromide, oleyl dimethylethylammonium bromide, lauryldimethylchlorethoxyethylammonium chloride, lauryldimethylbenzylammonium chloride, alkyl(C.sub.8 -C.sub.18) dimethyl (3,4-dichlorobenzyl)-ammonium chloride, lauryl isoquinolinium bromide, N(lauroyloxyethylaminoformylmethyl)pyridinium chloride and mixtures thereof.
A method for retarding the development of dental calculus, which comprises contacting tooth surfaces with an anticalculus composition comprising from about 0.05% to about 1.5% zinc ions, and about 0.03% to about 0.5% of a non-toxic, organoleptically acceptable antibacterial agent capable of inhibiting the growth of gram-positive oral microflora for at least about three hours, in an orally acceptable medium, said antibacterial agent being selected from the group consisting of 3,4',5-tribromosalicylanilide, the zinc derivative of 3,4',5-tribromosalicylanilide, 3,4',5-trichlorosalicylanilide, the zinc derivative of 3,4',5-trichlorosalicylanilide, 3,5-dibromo-4'-trifluoromethylsalicylanilide, the zinc derivative of 3,5-dibromo-4'-trifluoromethylsalicylanilide, 2,4,4'-trichloro-2'-hydroxydiphenyl ether, tyrothricin, chlorhexidine digluconate, chlorhexidine diacetate, quaternary ammonium compounds wherein said quaternary ammonium compounds are diisobutylphenoxyethoxyethyldimethylbenzylammonium chloride, diisobutylcresoxyethoxyethyldimethylbenzylammonium chloride, N-methyl-N-(2-hydroxyethyl)-N-(2-hydroxydodecyl)-N-benzyl ammonium chloride, cetyl trimethylammonium bromide, stearlyl trimethylammonium bromide, oleyl dimethylethylammonium bromide, lauryldimethylchloretoxylethylammonium chloride, lauryldimethylbenzylammonium chloride, alkyl(C.sub.8 -C.sub.18)dimethyl(3,4-dichlorobenzyl)-ammonium chloride, lauryl isoquinolinium bromide, N(lauroyloxyethylaminoformylmethyl)pyridinium chloride and mixtures thereof.
Dependencies are inferred from the claim text.