Antibacterially active hexamethylene-bis-biguanides
AssigneeA/S Farmaceutisk Industri
InventorHelge Guttorm Gundersen
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Abstract
There are disclosed new hexamethylene-bis-biguanides having antibacterial activity, and two processes for the preparation thereof. The new compounds have the general formula ##STR1## wherein R represents H, and R' represents an hexyl or pentyl group being substituted with one or two methyl groups, or represents a cycloalkyl group having more than 6 carbon atoms, a lower-alkyl-cycloalkyl group or a cycloalkyl-lower-alkyl group, or R and R' together with the adjacent nitrogen atom represent an azabicyclo(3,2,2)-nonane double ring.
Claims5
A compound of the formula ##STR6## wherein R represents H and R' is selected from the group consisting of 1-adamantyl, 2-norbonyl and cyclohexylmethyl or wherein R and R' together with the adjacent nitrogen atom form a 3-azabicyclo(3,2,2)-nonane double ring and pharmaceutically acceptable acid addition salts.
Dependencies are inferred from the claim text.