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US 4,020,153 AGranted
Cyclic sulphonamides and sulphinamides having a physiological cooling effect
AssigneeWilkinson Sword Limited
InventorsDavid G. Rowsell, David J. Spring
Life of this patent
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Abstract
Compositions are disclosed having a physiological cooling action on the skin. The compositions contain, as the active ingredient certain cyclic sulphonamides and sulphinamides.
Claims11
In a comsumer product manufactured for application to or consumption by the human person and being:
- a. a personal care product comprising a topically or orally administrable base medium containing a flavourant, perfume or antiseptic ingredient;
- b. a pharmaceutical preparation comprising a topically or orally administrable base medium containing a pharmaceutically active ingredient;
- or
- c. a tobacco-containing consumer product;
- said consumer product is also containing an ingredient capable of stimulating the cold receptors of the nervous system of the surface tissues of the body when brought into contact therewith by application or consumption of the said consumer product, the improvement which comprises using as the cold receptor stimulating ingredient an effective amount of a cold receptor stimulating cyclic sulphonamide or sulphinamide of the formula:
- ##STR5## where R is C.sub.1 -C.sub.5 alkyl;
- R.sub.1 and R.sub.2, when taken separately, are each hydrogen, C.sub.1 -C.sub.6 alkyl or C.sub.1 -C.sub.6 hydroxyalkyl, and together provide a total of no more than 6 carbon atoms, with the proviso that when R.sub.1 is hydrogen R.sub.2 may also be alkylcarboxyalkyl or up to 6 carbon atoms;
- x is an integer of from 1-2 inclusive;
- and
- n in an integer of from 1-4 inclusive.
7 more elements
A method of stimulating the cold receptors of the nervous system of the surface tissues of the human body, which comprises bringing into contact with said tissues an effective amount of a cold receptor stimulating cyclic sulphonamide or sulphinamide of the formula:
- ##STR7## where R is C.sub.1 -C.sub.5 alkyl;
- R.sub.1 and R.sub.2, when taken separately, are each hydrogen, C.sub.1 -C.sub.6 alkyl or C.sub.1 -C.sub.6 hydroxyalkyl, and together provide a total of no more than 6 carbon atoms, with the proviso that when R.sub.1 is hydrogen R.sub.2 may also be alkylcarboxyalkyl or up to 6 carbon atoms;
- x is an integer of from 1-2 inclusive;
- and
- n is an integer of from 1-4 inclusive.
2 more elements
Dependencies are inferred from the claim text.