Continuous process of producing pancreatin and product thereof
AssigneeKali-Chemie Pharma GmbH
InventorsHans Hell, Gunter Peschke, Horst Oppermann, Rudolf Kaufung, Siegfried Funke, Werner Stuhmer
Life of this patent
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Abstract
A freely flowable pancreatin of high amylolytic, lipolytic, and proteolytic activity, of a low germ content and substantially free of pathogenic germs and fibrous tissue material, of a high bulk weight between about 500 g./liter and about 700 g./liter and a very fine particulate size is produced according to the continuous process of extracting finely comminuted pancreas glands with a mixture of chlorinated hydrocarbons and fluoro-chloro-carbons and, if required, water, separating the fat-containing solvent phase, and recovering pancreatin from the enzyme phase.
Claims13
A process of producing pancreatin of a high amylolytic, lipolytic, and proteolytic activity, said pancreatin having a low germ content and being substantially free of fibrous tissue material, comprising the steps of:
- a. contacting frozen, finely comminuted pancreas glands with a mixture of liquid chlorinated hydrocarbon and of a liquid fluoro-chloro-carbon, wherein the ratio of chlorinated hydrocarbon to fluoro-chloro-carbon is between 1:0.05 and 1:2.0, for a period of time sufficient to remove the fat therefrom and to destroy the pathogenic germs;
- b. separating the fat-solvent phase from the enzyme phase;
- c. concentrating the enzyme phase;
- and
- d. drying the concentrated enzyme phase.
Dependencies are inferred from the claim text.