N.sup.2 -alkoxynaphthalenesulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof
AssigneesMitsubishi Chemical Industries Limited, Shosuke Okamoto
InventorsShosuke Okamoto, Ryoji Kikumoto, Kazuo Ohkubo, Tohru Tezuka, Shinji Tonomura, Yoshikuni Tamao, Akiko Hijikata
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Abstract
N.sup.2 -alkoxynaphthalenesulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof have been found to be effective as pharmaceutical agents for the inhibition and suppression of thrombosis.
Claims5
N.sup.2 -alkoxynaphthalenesulfonyl-L-argininamides having the formula:
- ##STR7## and the pharmaceutically acceptable salts thereof, wherein R.sub.1 is naphthyl substituted with at least one C.sub.1 -C.sub.5 alkoxy;
- R.sub.2 is C.sub.2 -C.sub.10 alkylthioalkyl;
- R.sub.3 is hydrogen, and n is an integer of 1, 2 or 3.
A method for inhibiting activity and suppressing activation of thrombin in vivo which comprises introducing into a living body a pharmaceutically effective amount of an N.sup.2 -alkoxynaphthalenesulfonyl-L-argininamide having the formula:
- ##STR8## or the pharmaceutically acceptable salts thereof, wherein R.sub.1 is naphthyl substituted with at least one C.sub.1 -C.sub.5 alkoxy;
- R.sub.2 is C.sub.2 -C.sub.10 alkylthioalkyl;
- R.sub.3 is hydrogen, and n is an integer of 1, 2 or 3.
Dependencies are inferred from the claim text.