Steroidal[16.alpha.,17-c][2H]pyrroles
AssigneeE. R. Squibb & Sons, Inc.
InventorsRavi K. Varma, Christopher M. Cimarusti
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Abstract
Steroids having the structure ##STR1## and the 1,2-dehydro derivatives thereof, wherein R.sub.1 is hydrogen, hydroxy, ##STR2## fluorine, chlorine, or bromine; R.sub.2 is alkyl or aryl; R.sub.3 is aryl, cyano, alkylcarbonyl, arylcarbonyl, alkoxycarbonyl, aryloxycarbonyl, alkylsulfonyl, or arylsulfonyl; R.sub.4 is carbonyl, .beta.-hydroxymethylene, .beta.-chloromethylene or .beta.-bromomethylene; R.sub.5 is hydrogen, fluorine, chlorine or bromine; and R.sub.6 is hydrogen, fluorine, or methyl; have useful antiinflammatory activity.
Claims10
A steroid having the formula ##STR10## or a 1,2-dehydro derivative thereof, wherein R.sub.1 is hydrogen, hydroxy, ##STR11## fluorine, chlorine or bromine;
- R.sub.2 is alkyl or aryl;
- R.sub.3 is aryl, cyano, alkylcarbonyl, arylcarbonyl, alkoxycarbonyl, aryloxycarbonyl, alkylsulfonyl, or arylsulfonyl;
- R.sub.4 is carbonyl, .beta.-hydroxymethylene, .beta.-chloromethylene, or .beta.-bromomethylene;
- R.sub.5 is hydrogen, fluorine, chlorine or bromine;
- and R.sub.6 is hydrogen, fluorine or methyl;
- wherein aryl is phenyl or phenyl substituted with fluorine, chlorine, bromine, nitro, cyano, alkyl or alkoxy;
- and alkyl and alkoxy are groups having 1 to 6 carbon atoms.
Dependencies are inferred from the claim text.