Optical analysis of biomedical specimens
AssigneeNeotec Corporation
InventorRobert D. Rosenthal
Life of this patent
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Abstract
A technique for automatic detection of abnormalities, particularly pathology, in biomedical specimens. Light transmittance or reflectance data over a large number of wavelengths for numerous samples are correlated mathematically with conventional clinical results to select test wavelengths and constants for a correlation equation. Optical instrumentation with an analog or digital computer applies the resulting correlation equation to the spectral data on a given specimen at the test wavelengths to determine quantitatively the presence of the abnormality.
Claims13
A method of detecting pathological abnormality in a multicellular bulk biomedical specimen comprising the steps of recording and analyzing light absorption spectrum data of the multicellular bulk specimen in accordance with a mathematical expression which correlates the spectrum data of a multiplicity of corresponding biomedical samples with the results of typing of said samples by clinical pathology.
A method of detecting the presence of a pathological abnormality in a multicellular bulk biomedical specimen, comprising the steps of illuminating the multicellular bulk specimen sequentially with a plurality of difference light wavelengths, recording selected light absorption dependent values within the sample's light output spectrum, computing the value of a mathematical function of said selected absorption-dependent values, said mathematical function being selected to produce a computed value which correlates with the presence or absence of said pathological abnormality, and comparing the level of the computed value to a predetermined screening level.
Dependencies are inferred from the claim text.