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US 4,012,367 AGranted
Anti-ulcer polypeptides containing L-aspartic acid and intermediates thereto
AssigneeG. D. Searle & Co.
InventorRobert H. Mazur
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Abstract
This invention encompasses novel tetrapeptide amides and their intermediates containing an L-aspartic acid residue. These peptides are inhibitors of gastric acid secretion and therefore useful in the treatment of ulcers.
Claims11
A compound of the formula
- A-Trp-Met-Asp-Y-NHR I
- wherein
- A is hydrogen, alkanoyl containing 2 to 6 carbon atoms, succinyl, t-butoxycarbonyl, benzyloxycarbonyl, D-pyroglutamyl or L-pyroglutamyl;
- Y is a radical of the formula ##STR19## wherein R' is an alkyl radical containing 1 to 6 carbon atoms or a methylcyclopentyl radical and the stereochemical configuration is D, or DL, or Y is a radical of the formula ##STR20## R is hydrogen or an alkyl radical containing 1 to 6 carbon atoms;
- and pharmaceutically acceptable acid addition salts thereof;
- and the optically active amino acid Trp, Met and Asp residues are of the L-configuration.
3 more elements
Dependencies are inferred from the claim text.