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US 4,009,847 AGranted
1-Tertiary-alkyl-3-(substituted thienyl)ureas and 1-tertiary-alkyl-3-(substituted thietyl)ureas as antihypertensive agents
AssigneeE. I. Du Pont de Nemours and Company
InventorsPaul Edward Aldrich, Gilbert Harvey Berezin, Bruce Ivor Dittmar
Life of this patent
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Abstract
This invention relates to a class of 1-tertiary-alkyl-3-(substituted thienyl)ureas and 1-tertiary-alkyl-3-(substituted thietyl)ureas that exhibit antihypertensive activity in warm-blooded animals. Representative compounds are 1-tert-butyl-3-(4,5-dihydro-3-thienyl)urea S,S-dioxide and 1-tert-butyl-3-(3-thiethyl)urea S,S-dioxide.
Claims15
A compound of the formula:
- ##STR64## where R.sub.1, R.sub.2 and R.sub.3 are C.sub.1 -C.sub.3 alkyl, or C.sub.2 -C.sub.3 alkenyl, with the provisos that the total number of carbon atoms of R.sub.1 plus R.sub.2 plus R.sub.3 does not exceed 5 ##STR65## R.sub.4 is H or CH.sub.3 with the proviso that when R.sub.4 is CH.sub.3, X is -CH.sub.2 CH.sub.2 -;
- and its sodium, potassium, or calcium salts.
Dependencies are inferred from the claim text.