Asymmetric catalysis
AssigneeMonsanto Company
InventorsWilliam S. Knowles, Milton J. Sabacky, Billy D. Vineyard
Life of this patent
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Abstract
New optically active bis phosphine compounds which are useful in optically active catalysts. Such catalysts are particularly useful in catalytic asymmetric hydrogenation.
Claims16
An optically active compound represented by the structural formula ##STR11## wherein A and B each independently represent substituted and unsubstituted alkyl of from 1 to 12 carbon atoms, substituted and unsubstituted cycloalkyl having from 4 to 7 carbon atoms, substituted and unsubstituted aryl, provided that such substituents provide no significant interference with the steric requirements around the phosphorus atom, either A or B must be an aryl group having an alkoxy substituent at the ortho position and A and B are different.
An optically active compound represented by the structural formula ##STR12## wherein A and B are dissimilar substituted or unsubstituted aryl groups;
- provided that substituents on the aryl groups provide no significant interference with the steric requirements around the phosphorus atom.
Optically active 1,2-bis(o-anisylphenylphosphino) ethane,
Optically active 1,2-bis(o-anisylcyclohexylphosphino) ethane.
Optically active 1,2-bis(o-anisylethylphosphino) ethane.
An optically active compound represented by the structural formula ##STR17## wherein A and B each independently represent substituted and unsubstituted alkyl of from 1 to 12 carbon atoms, substituted and unsubstituted cycloalkyl having from 4 to 7 carbon atoms, substituted and unsubstituted aryl;
- provided that such substituents provide no significant interference with the steric requirements around the phosphorus atom and A and B are different.
Optically active 1,2-bis(o-anisylphenylphosphinyl) ethane.
Optically active 1,2-bis(o-anisylcyclohexylphosphinyl) ethane.
Optically active 1,2-bis(o-anisylethylphosphinyl) ethane.
Dependencies are inferred from the claim text.