Pharmaceutical compositions and their administration for the prophylaxis of asthma, hayfever and rhinitis
AssigneeBeecham Group Limited
InventorsDerek Richard Buckle, Harry Smith
Life of this patent
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Abstract
Nitro-indane-diones, their production, and pharmaceutical compositions and their administration in forms suitable for the prophylaxis of asthma, hayfever and rhinitis in amounts effective for oral, parenteral and insufflation administration for such forms. The compounds are nitro-indane-diones of the formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 have certain designated meanings, obtained by nitration of a parent un-nitrated compound and wherein ring A contains 1 or 2 double bonds.
Claims22
A pharmaceutical composition in a form suitable for oral, parenteral or insufflation administration to humans which comprises an amount of a compound of the formula (I) or a salt thereof:
- ##STR4## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each hydrogen, lower alkyl, phenyl, benzyl, lower alkoxy, lower acyloxy, carboxy, lower alkoxycarbonyl or halogen, and wherein the ring marked A contains 1 or 2 double bonds, sufficient to be effective for the prophylaxis of asthma, hayfever or rhinitis in combination with a pharmaceutically-acceptable, nontoxic, inert diluent or carrier suitable for said administration form.
Dependencies are inferred from the claim text.