Diagnostic process using sodium tyropanoate
AssigneeSterling Drug Inc.
InventorThomas W. Skulan
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Abstract
Divided doses or sustained release formulations of sodium tyropanoate upon oral administration provide adequate gallbladder visualization with substantially lower blood levels than are obtained with conventional single dose administration.
Claims3
A process which comprises administering orally to a mammal possessing a gallbladder, a single undivided dose in a sustained or controlled release formulation or intermittently over a period of between about four and about ten hours, an amount of sodium tyropanoate of between about 25 and 100 milligrams per kilogram of body weight of the mammal, whereby a concentration of iodine in the gallbladder sufficient to provide adequate X-ray visualization of the gallbladder is obtained, while maintaining the maximum iodine concentration in the blood significantly lower than the maximum iodine concentration in the blood obtained by oral administration of an initial single dose of the same total amount of sodium tyropanoate.
A process which comprises administering orally to a mammal possessing a gallbladder a sustained release formulation comprising an amount of sodium tyropanoate of between about 25 and 100 milligrams per kilogram of body weight of the mammal, whereby a concentration of iodine in the gallbladder sufficient to provide adequate X-ray visualization of the gallbladder is obtained while maintaining the maximum iodine concentration in the blood significantly lower than the maximum iodine concentration in the blood obtained by oral administration of the same amount of sodium tyropanoate alone.
Dependencies are inferred from the claim text.