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US 4,001,200 AGranted
Novel polymerized, cross-linked, stromal-free hemoglobin
AssigneeAlza Corporation
InventorsPieter Bonsen, Myron B. Laver, Kent C. Morris
Life of this patent
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Abstract
This invention concerns polymerized, cross-linked, stromal-free hemoglobin useful as a blood substitute for carrying oxygen to tissues and organs, as a blood plasma expander and for supplying oxygen to oxygen-requiring environments.
Claims6
Polymerized, cross-linked, stromal-free hemoglobin, soluble in aqueous and physiological fluids, capable of reversibly binding a ligand, having a molecular weight of 64,000 to 1,000,000 and the formula poly(Hb).sub.n wherein Hb is a member selected from the group consisting of a stromal-free monomer, dimer, trimer and tetramer hemoglobin, and n is 4 to 60.
Dependencies are inferred from the claim text.