Water dispersible carotenoid preparations and processes thereof
AssigneeHoffmann-La Roche Inc.
InventorsThomas William Antoshkiw, Marco Alfred Cannalonga, Arnold Koff
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Abstract
This invention relates to water dispersible carotenoid compositions in liquid or powder form which are suitable for use in the preparation of colored optically clear, stable, aqueous compositions and which can be incorporated into, e.g., pharmaceutical or cosmetic preparations or animal feedstuff and to processes for their preparation.
Claims21
A process for the preparation of a water-dispersible carotenoid-containing powder wherein the carotenoid has a particle size of less than 0.1 micron which comprises the steps of
- a. forming a solution of a carotenoid and an antioxidant in a volatile organic solvent for the carotenoid, said volatile organic solvent selected from the group consisting of halogenated aliphatic hydrocarbons, benzene and carbon disulfide;
- b. forming an aqueous solution of sodium lauryl sulfate, a water-soluble carrier composition, a preservative and a stabilizer, and adjusting said solution to a pH of about 10 to 11;
- c. forming an emulsion of the solutions of steps (a) and (b) using both mixing at a high speed and high shear;
- d. removing the organic solvent while maintaining both high speed mixing and high shear;
- adjusting the solids content of the emulsion using water and
- f. spray-drying the resulting emulsion to obtain the water-dispersible, carotenoid-containing powder.
A process for the preparation of an aqueous emulsion wherein the carotenoid component in the dispersed oil phase has a particle size of less than 0.1 micron which comprises the steps of:
- a. forming a solution of a carotenoid and an antioxidant in a volatile organic solvent for the carotenoid, said volatile organic solvent selected from the group consisting of halogenated aliphatic hydrocarbons, benzene and carbon disulfide;
- b. forming an aqueous solution of sodium lauryl sulfate, a water-soluble carrier composition, a preservative and a stabilizer, and adjusting said solution to a pH of about 10 to 11;
- c. forming an emulsion of the solutions of steps (a) and (b) using both mixing at a high speed and high shear and
- d. removing the organic solvent while maintaining both high speed mixing and high shear
- to obtain the carotenoid component in the aforesaid particle size.
Dependencies are inferred from the claim text.