Steroidal 16.beta.-alkyl[16.alpha.,17-b]naphthalenes
AssigneeE. R. Squibb & Sons, Inc.
InventorsRavi K. Varma, Christopher M. Cimarusti
Life of this patent
Estimating the term…
Abstract
Novel steroids having the structure ##SPC1## And the 1,2-dehydro derivatives thereof, wherein R.sub.1 is chlorine, fluorine, or hydroxy and R'.sub.1 is hydrogen or R.sub.1 and R'.sub.1 together are =O; R.sub.2 is hydrogen or halogen; R.sub.3 is hydrogen, methyl, or fluorine; R.sub.4 is hydrogen, hydroxy, ##EQU1## or halogen; R.sub.5 and R.sub.6 are the same or different and are hydrogen, alkyl, alkoxy, carboalkoxy, formyl, ##EQU2## hydroxy, halogen, phenyl or cyano, with the proviso that when R.sub.5 and R.sub.6 are different, one of R.sub.5 and R.sub.6 is hydrogen; and R.sub.7 and R.sub.8 are the same or different and are hydrogen or alkyl.
Claims8
A steroid having the formula ##SPC11##
- or the 1,2-dehydro derivatives thereof, wherein R.sub.1 is chlorine, fluorine or hydroxy and R'.sub.1 is hydrogen, or R.sub.1 and R'.sub.1 together are =O;
- R.sub.2 is hydrogen or halogen;
- R.sub.3 is hydrogen, methyl or fluorine;
- R.sub.4 is hydrogen, hydroxy, ##EQU3## or halogen;
- R.sub.5 and R.sub.6 are the same or different and are hydrogen, alkyl, alkoxy, carboalkoxy, formyl, ##EQU4## hydroxy, halogen, phenyl or cyano, with the proviso that when R.sub.5 and R.sub.6 are different, one of R.sub.5 and R.sub.6 is hydrogen;
- and R.sub.7 and R.sub.8 are the same or different and are hydrogen or alkyl.
A steroid having the formula ##SPC12##
- or the 1,2-dehydro derivative thereof, wherein R.sub.3 is hydrogen, methyl, or fluorine;
- R.sub.4 is hydrogen, hydroxy, ##STR4## or halogen;
- R.sub.5 and R.sub.6 are the same or different and are hydrogen, alkyl, alkoxy, carboalkoxy, formyl, ##STR5## hydroxy, halogen, phenyl, or cyano, with the proviso that when R.sub.5 and R.sub.6 are different, one of R.sub.5 and R.sub.6 is hydrogen;
- and R.sub.7 and R.sub.8 are the same or different and are hydrogen or alkyl.
Dependencies are inferred from the claim text.