Controlled release of medicaments using polymers from glycolic acid
AssigneeAmerican Cyanamid Company
InventorsEdward Emil Schmitt, Rocco Albert Polistina
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Abstract
Polyhydroxyacetic ester, also called polyglycolic acid (PGA), has surgically useful mechanical properties. On implantation, in living mammalian tissue, the polyglycolic acid is absorbed, and replaced by living tissue. Sutures, clips and storage pellets having medicaments incorporated therein can be used for both their own mechanical properties and as a delayed release system for medicaments.
Claims5
A controlled release medicament device consisting of at least one filament of polyglycolic acid having incorporated therein a small but effective amount of an antibiotic.
A medicament repository consisting of a surgical element in the form of tubes, sheets, sponges, gauzes or prosthetic devices of polyglycolic acid having incorporated therein an effective amount of a medicament.
In a surgical needle and suture combination the improvement comprising:
- a suture consisting of at least one filament of stretched and oriented normally solid polyglycolic acid,
- the said surgical needle and suture being sterile;
- the said suture
- having good knotability, good knot strength, good handleability, ready colorability, and a total denier of from 1 to 4,000,
- retaining a high proportion of its original strength for at least 3 days when embedded in living muscular tissue,
- being substantially absorbed in 90 days when embedded in living muscular tissue,
- and being substantially free from contaminants not absorbable by living muscular tissue,
- and having incorporated therein a small but effective quantity of an antibiotic, antiseptic, or anesthetic,
Dependencies are inferred from the claim text.