Anti-inflammatory agents
AssigneeEli Lilly and Company
InventorsWinston S. Marshall, William Pfeifer
Life of this patent
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Abstract
This invention is directed to the use of certain arylacetylene compounds, principally as anti-inflammatory agents but also as anti-pyretic agents and as analgesic agents.
Claims8
A method of treating inflammation in a warm-blooded animal which comprises administering to the animal an effective amount of an active agent which is a compound of the formula:
- ##SPC4##
- wherein q represents 0, 1, or 2;
- each R.sup.1 independently represents chloro or fluoro;
- and R.sup.2 represents
- 1. phenyl;
- and
- 2. substituted phenyl of the formula ##SPC5##
- wherein each R.sup.3 independently represents chloro or fluoro and n represents 1 or 2;
- provided that q must be other than 0 when R.sup.2 is phenyl.
A method of treating inflammation, fever or pain in a warm-blooded animal which comprises administering to the animal an effective amount of an active agent which is a compound selected from the group consisting of (4-(2-fluorophenyl)phenyl)acetylene, (3-fluoro-4-phenylphenyl)acetylene, and (4-(2,4-difluorophenyl)phenyl)acetylene.
A pharmaceutical preparation in a dosage unit form adapted for oral administration to obtain an anti-inflammatory, anti-pyretic, or analgesic effect, comprising, per dosage unit, an effective non-toxic amount within the range from about 1 to about 1000 milligrams of an active agent, and a pharmaceutical diluent, said active agent being either (4-(2-fluorophenyl)phenyl)acetylene or (3-fluoro-4-phenylphenyl)acetylene.
Dependencies are inferred from the claim text.