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US 3,991,087 AGranted
8-Halo-11,12-secoprostaglandins
AssigneeMerck & Co., Inc.
InventorsEdward J. Cragoe, Jr., John B. Bicking
Life of this patent
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Abstract
This invention relates to 11,12-secoprostaglandins and processes for their manufacture. These compounds have prostaglandin-like biological activity and are particularly useful as renal vasodilators, for the treatment of hypertension, and for the prevention of thrombus formation.
Claims19
The compound having the following formula:
- ##EQU1## wherein R is carboxy, a carboxy salt, or a carboxy alkyl ester;
- A is ethylene, trimethylene, .alpha.-methylethylene, .beta.-methylethylene, .alpha.,.alpha.-dimethylethylene, or .beta.,.beta.-dimethylethylene;
- Q is chloro or bromo;
- R.sup.1 is hydrogen or methyl;
- R.sup.2 is hydrogen;
- R.sup.3 is hydrogen or methyl;
- and
- R.sup.4 is hydrogen or loweralkyl.
5 more elements
Dependencies are inferred from the claim text.