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US 3,989,749 AGranted
11,12-Secoprostaglandins
AssigneeMerck & Co., Inc.
InventorsEdward J. Cragoe, Jr., James H. Jones
Life of this patent
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Abstract
This invention relates to 8,10-diaza-9-oxo(and thioxo)-11,12-secoprostaglandins and processes for their manufacture. These compounds have prostaglandin-like biological activity and are particularly useful as renal vasodilators, and for the prevention of thrombus formation.
Claims30
The compound having the following formula:
- ##EQU1## wherein R is carboxy, a carboxy salt, said salt being formed from a pharmaceutically acceptable cation selected from the group of metals and amines, or derivatized carboxy having the formula
- --COOY
- wherein
- Y is alkyl having 1-10 carbon atoms;
- A is ethylene, trimethylene, .alpha.-methylethylene, .beta. -methylethylene, .alpha.,.alpha.-dimethylethylene, or .beta., .beta.-dimethylethylene;
- R.sup.1 is carbamoyl or thiocarbamoyl;
- Z is methylene, ethylene, trimethylene, tetramethylene, vinylene, or ethynylene;
- R.sup.2 is independently hydrogen or methyl;
- R.sup.3 is hydrogen or loweralkanoyl;
- R.sup.4 is selected independently from the group consisting of hydrogen and methyl;
- R.sup.5 is selected from the group consisting of hydrogen, lower alkyl of 1-4 carbon atoms, vinyl and 2,2,2-trifluoroethyl.
8 more elements
Dependencies are inferred from the claim text.