Processes for the deuteration and/or tritiation of organic substrates by hydrogen substitution
AssigneeCanadian Patents and Development Limited
InventorsNick Henry Werstiuk, Tonu Kadai
Life of this patent
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Abstract
In processes for the deuteration and/or tritiation of cyclic organic substrates by hydrogen substitution, the substrate is subjected at a temperature of between about 200.degree. and 400.degree. C to the effect of a 0.10% to 10% V/V dilute solution of a strong acid in the respective oxide constituting the isotope pool for the exchange. A deuterated or tritated acid may be used. Rapid exchange in the aromatic ring and high yields are obtained with apparent freedom from side reactions and decomposition.
Claims10
A process for the deuteration or tritiation of organic substrates containing at least one unsaturated aromatic ring selected from benzene rings and pyridine rings by hydrogen substitution and being capable of carbonium ion formation, wherein the substrate is subjected to the effects of a 0.10 to 10% v/v dilute solution of a strong acid in deuterium or tritium oxide respectively at a temperature between 200.degree. and 400.degree. C.
A process for the deuteration or tritiation of a cyclic organic substrate by hydrogen substitution, the substrate containing unsaturation and being capable of carbonium ion formation at the site of the double bond, the said substrate having a benzene nucleus, and wherein the substrate is subjected to the effects of a 0.10 to 10% V/V dilute solution of a strong acid in deuterium or tritium oxide respectively at a temperature between about 200.degree. and 400.degree. C.
Dependencies are inferred from the claim text.